While home parenteral nutrition (HPN) is the primary treatment for short bowl syndrome with intestinal failure (SBS-IF), intestinal transplantation is reserved for people who cannot be adequately managed through HPN.1

Intestinal transplantation is a life-saving treatment that is used for people on HPN who develop serious complications such as liver disease. According to guideline recommendations by the ESPEN medical society of experts, it may also be recommended for patients experiencing malnutrition and dehydration even when they are managed with HPN.1

The ESPEN guidelines recommend transplantation only in patients with a high morbidity and mortality risk. Therefore, the mortality rates need to be reflected fairly in this context.1



The main treatment goal of SBS-IF is to cure intestinal failure and achieve a full recovery by lowering time spent on parenteral support (PS).1

Reversal of SBS-IF could be a reality for up to half of people with SBS-IF, depending on the underlying characteristics of their disease. Chronic IF in people with SBS-IF may be reversed through structural and functional changes to the remaining intestine as a result of medical and surgical treatments.1

However, complete freedom from PS in people with SBS-IF is relatively unlikely to occur after 2–3 years have passed from the most recent intestinal resection.1


There is a need for treatments in SBS-IF that improve the ability of the remaining intestine to absorb nutrients and partially or completely stop treatment with PS.2–4

Substantial research is being conducted in SBS-IF to offer treatments that will help to increase life expectancy, reduce complications associated with PS and maximise quality of life.2,3

New treatments hold great promise in helping to improve intestinal function with the aim of enabling freedom from PS for people with SBS-IF.1–3,5,6







Speak with your doctor to find out more about treatments for people with SBS-IF.



Date of preparation: April 2020 C-ANPROM/INT//7389