SBS results from either the physical loss of sections of the small intestine or from disease that prevents the small intestine from functioning properly despite normal length.1–4
- This usually occurs because the individual has had to have a large section of the bowel removed by surgery (Figure 1)
- This could be due to complications of Crohn's disease, problems with the blood supply to the small intestine, cancer, a twisting or obstruction of the intestine, or even trauma and complications from other abdominal surgery1–4
- This is much less common than physical loss, and happens when the patient is unable to absorb enough nutrients even though they have an intact intestine
- Functional loss can be caused by: inflammatory bowel disease, a pseudo-obstruction of the intestine, inflammation of the intestine due to radiation therapy (radiation enteritis), or a rare genetic disorder called congenital villus atrophy that causes chronic diarrhoea1–4
- Hofstetter S, Stern L, Willet J. Key issues in addressing the clinical and humanistic burden of short bowel syndrome in the US. Curr Med Res Opin 2013;29(5):495–504.
- Jeppesen PB. Spectrum of short bowel syndrome in adults: intestinal insufficiency to intestinal failure. JPEN J Parenter Enteral Nutr 2014;38(1 Suppl):8S–13S.
- O'Keefe SJ, Buchman AL, Fishbein TM, et al. Short bowel syndrome and intestinal failure: consensus definitions and overview. Clin Gastroenterol Hepatol 2006;4(1):6–10.
- Buchman AL, Scolapio J, Fryer J. AGA technical review on short bowel syndrome and intestinal transplantation. Gastroenterology2003;124(4):1111–34.
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